Insights on sex-specific factors and Alzheimer’s

Medical News Today also spoke with Dr. Verna Porter, a neurologist and director of the Dementia, Alzheimer’s Disease, and Neurocognitive Disorders at Providence Saint John’s Health Center in Santa Monica, CA, about this study.

As a doctor treating female patients at high risk for Alzheimer’s disease, she said she found this study to be one of great interest.

“The findings presented in the study provide valuable insights into the role of sex-specific factors, particularly the impact of estradiol and cholinergic signaling, in Alzheimer’s disease.

Understanding these factors can significantly influence how I approach risk assessment and discussions with female patients, especially those in the perimenopausal age range. In future discussions with my female patients, I would use these findings to provide a more personalized and informative approach to Alzheimer’s risk assessment and management.”

Dr. Verna Porter

Dr. Porter said these findings may also lead to a need to emphasize the importance of considering the patient’s hormonal status, including their menopausal stage and the role of estradiol, when assessing their Alzheimer’s risk.

“This would be particularly relevant for perimenopausal women, as the study suggests that estradiol may impact the relationship between cholinergic signaling and amyloid pathology,” she added.

“For those in the perimenopausal age range, we should continue to stress the importance of monitoring cognitive health and considering lifestyle modifications, such as maintaining cognitive stimulationTrusted Source and a healthy dietTrusted Source, which have been associated with a reduced risk of Alzheimer’s disease,” Dr. Porter said.